Table 1.
Pre-clinical studies of T4 nanoparticle vaccine candidates.
| Organism | Antigens (kDa) | Animal model | Capsid proteins | References |
|---|---|---|---|---|
| Bacillus anthracis | PA(83 kDa), LF (89 kDa), Toxin complex (710 kDa) | None | Soc | [132,139,143] |
| Bacillus anthracis | PA(83 kDa), LF (89 kDa), EF (89 kDa) | Mouse | Hoc | [110,140] |
| Bacillus anthracis | PA(83 kDa) | Rabbit | Hoc, Soc | [111] |
| Bacillus anthracis | PA(83 kDa) | Rhesus macaque | Hoc, Soc | [112] |
| Yersinia pestis | LcrV (37 kDa), Caf1 (16 kDa), YscF (11.8 kDa) | Mouse, Rat | Soc | [55, 92, 138] |
| Neisseria meningitidis | PorA peptide (16.9 kDa) | None | Hoc, Soc | [137] |
| HIV-1 | p24 (26 kDa), Nef (31 kDa), gp41 (21 kDa) | Mouse | Soc | [86] |
| HIV-1 | gp41 (39 kDa) | None | Soc | [79] |
| HIV-1 | V3 loop of gp120 (5 kDa) | None | Soc | [136] |
| Foot-and-mouth disease virus | P1 (89 kDa), proteinase 3C (24 kDa) | Mouse, Pig | Soc | [144] |
| Classical swine fever virus | E2 (44 kDa) | Mouse | Hoc, Soc | [145] |
| Bursal disease virus | VP2 (40.0 kDa) | Chicken | Soc | [146] |
| Poliovirus | VP1 (34.5 kDa) | None | Soc | [136] |