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. 2019 Sep 18;10:1145. doi: 10.3389/fphys.2019.01145

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Copyright © 2019 Vaněčková, Hojná, Vernerová, Kadlecová, Rauchová, Kompanowska-Jezierska, Vaňourková, Červenka and Zicha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of diuretic treatment added to combined RAS and ET_A blockade on histological markers of renal damage. Glomerulosclerosis index (A) and kidney tubulointerstitial injury (B) in sham-operated heterozygous Ren-2 transgenic rats (TGR-sham), nephrectomized TGR (TGR-NX) treated with the renin-angiotensin system blockade alone (RAS), combined RAS + ET_A blockade (RAS + ET_A); or diuretic given with the combined RAS + ET_A blockade (RAS + ET_A + Diu). Diu – diuretic # P < 0.05 TGR-sham vs. other TGR-NX-treated groups, $ P < 0.05 TGR-NX + RAS treated vs. other TGR-NX-treated groups, @ P < 0.05 TGR-NX + RAS + ET_A + diuretic vs. other TGR-NX-treated groups.