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. 2019 Sep 18;10:1145. doi: 10.3389/fphys.2019.01145

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Copyright © 2019 Vaněčková, Hojná, Vernerová, Kadlecová, Rauchová, Kompanowska-Jezierska, Vaňourková, Červenka and Zicha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images of renal histology. Renal parenchyma without morphological alterations in control sham-operated HanSD rats (HanSD-sham). Extensive secondary focal segmental glomerulosclerosis and small zone of atrophic tubules (the upper right part) in sham-operated heterozygous Ren 2 transgenic rats (TGR-sham). RAS blockade only partially improved morphology of renal parenchyma; focal segmental glomerulosclerosis persists as well as glomerular enlargement in nephrectomized TGR (TGR-NX + RAS). Combined RAS and ETA blockade substantially atenuated renal injury in nephrectomized TGR; glomeruli contain segmental tuft sclerosis only sporadically (TGR-NX + RAS + ET_A blockade). Treatment with diuretic added to the combined RAS+ETA blockade most significantly protected renal parenchyma from injury in nephrectomized TGR (TGR-NX + RAS + ET_A blockade + diuretic). Periodic acid-Schiff staining. Magnification 200×.