Table VI.

Variables influencing ∆Cp values determined using univariate and multivariate analyses (Cox proportional hazard model).

	Univariate analysis				Multivariate analysis
Variable	Cases (n=214)a	OR	95% CI	P-value	OR	95% CI	P-value
Intra-tubular necrosis		2.15	0.83-5.56	0.1143
Absence	21
Presence	193
Extra-tubular necrosis		1.51	0.88-2.60	0.1322
Absence	115
Presence	99
Mucus pool		1.00	0.34-2.96	1.0000
Absence	200
Presence	14
Tumor Budding		0.77	0.32-1.83	0.8152
Grade 1	145
Grade 2	45
Grade 3	24
Histological differentiation		1.55	0.53-4.51	0.4248
Well/Moderate	199
Poor/Undifferentiated	15
Grading (WHO classification)		1.55	0.53-4.51	0.4248
Grade 1/2	199
Grade 3/4	15
Desmoplasia		0.75	0.43-1.32	0.3164
Absence	139
Presence	75
Excessive infiltration of inflammatory cells		0.83	0.42-1.65	0.6031
Absence	173
Presence	41
Microabscess		0.83	0.41-1.66	0.5962
Absence	175
Presence	39
Burning effect		1.28	0.48-3.37	0.6230
Absence	196
Presence	18
RTCb		0.73	0.29-1.80	0.4920
>50%	21
≤50%	193
Metastatic tumor		3.86	1.72-8.65	0.0010	4.43	1.87-10.49	0.0007
No	177
Yes	37
Tumor area using log-scale (mm2)		0.87	0.65-1.16	0.3307
>58.1
≤58.1
Laser microdissection		0.49	0.09-2.74	0.4167
No	208
Yes	6
Storage time (years)		4.82	2.00-11.64	0.0005	5.51	2.18-13.95	0.0003
>3	34
≤3	180

^aFour patients with missing ∆Cp values were excluded;

^bratio of tumor cells to the total number of cells.