Table 4.
Allelic frequency of methylenetetrahydrafolate reductase C677T and A1298C polymorphism in control, deep vein thrombosis and coronary artery disease patients
| MTHFR polymorphism | Control (n=120), n (%) | DVT (n=120), n (%) | CAD (n=120), n (%) | Crude ORa (95% CI) | Crude ORb (95% CI) |
|---|---|---|---|---|---|
| MTHFR6C77T | |||||
| C/C | 104 (86.67) | 91 (75.83) | 88 (73.33) | 1.0 (reference) | 1.0 (reference) |
| C/T | 15 (12.50) | 25 (20.83) | 29 (24.17) | 1.90 (0.95-3.83) | 2.28* (1.15-4.53) |
| T/T | 1 (0.83) | 4 (3.33) | 3 (2.50) | 4.57 (0.50-41.66) | 3.54 (0.36-34.71) |
| CT + TT | 16 (13.33) | 29 (24.16) | 32 (26.67) | 2.07* (1.06-4.06) | 2.36* (1.22-4.59) |
| Allele frequency | |||||
| C | 0.93 | 0.86 | 0.85 | ||
| T | 0.07 | 0.14 | 0.15 | ||
| MTHFR A1298C | |||||
| AA | 49 (40.83) | 55 (45.83) | 58 (48.33) | 1.0 (reference) | 1.0 (reference) |
| AC | 68 (56.67) | 51 (42.50) | 54 (45.00) | 0.67 (0.39-1.13) | 0.67 (0.40-1.13) |
| CC | 3 (2.50) | 14 (11.67) | 8 (6.67) | 4.16* (1.13-15.34) | 2.25 (0.57-8.96) |
| AC + CC | 71 (59.17) | 65 (54.17) | 62 (51.67) | 0.81 (0.49-1.36) | 0.74 (0.44-1.23) |
| Allele frequency | |||||
| A | 0.69 | 0.67 | 0.71 | ||
| C | 0.31 | 0.33 | 0.29 |
*P<0.05 as compared to reference genotype using Chi-square analysis, aOR=OR for DVT and, bOR=OR for CAD. OR=Odd ratio, CI=Confidence interval, DVT=Deep vein thrombosis, CAD=Coronary artery disease, MTHFR=Methylenetetrahydrafolate reductase