Table IV.
NOx, adiponectin and enothelin-1 levels in male and female patients with various SNP genotypes of the ADIPOQ gene.
| A, rs17366743 SNP | |||||
|---|---|---|---|---|---|
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 307 | 8 | 0 | |
| F | 125 | 6 | 1 | ||
| NOx (µМ) | M | 32.61±19.78 | 34.16±11.21 | - | 0.39 |
| F | 26.66±19.91 | 42.95±31.70 | 65.47 | 0.10 | |
| Adiponectin (µg/ml) | M | 8.96±5.93 | 8.98±4.29 | - | 0.99 |
| F | 11.33±7.27 | 15.11±14.15 | 19.24 | 0.96 | |
| Endothelin (fmol/ml) | M | 2.68±4.95 | 1.11±0.71 | - | 0.04 |
| F | 2.84±3.59 | 5.53±6.62 | 1.79 | 0.46 | |
| B, rs17300539 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 273 | 40 | 2 | |
| F | 112 | 20 | 0 | ||
| NOx (µМ) | M | 32.67±19.64 | 33.08±20.00 | 32.51±8.44 | 0.99 |
| F | 26.69±20.39 | 35.28±24.00 | - | 0.21 | |
| Adiponectin (µg/ml) | M | 8.74±5.69 | 10.44±7.13 | 7.02±1.07 | 0.23 |
| F | 11.69±8.05 | 11.23±5.25 | - | 0.63 | |
| Endothelin (fmol/ml) | M | 2.68±3.33 | 2.39±3.55 | 1.39±0.16 | 0.35 |
| F | 3.00±3.73 | 2.48±3.71 | - | 0.48 | |
| C, rs266729 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 170 | 112 | 33 | |
| F | 70 | 42 | 20 | ||
| NOx (µМ) | M | 31.94±17.05 | 31.75±18.81 | 39.45±30.94 | 0.63 |
| F | 26.71±19.67 | 27.32±22.65 | 32.70±22.48 | 0.40 | |
| Adiponectin (µg/ml) | M | 9.42±6.23 | 8.90±5.87 | 6.76±3.33 | 0.44 |
| F | 11.23±7.10 | 12.41±8.28 | 10.97±8.45 | 0.88 | |
| Endothelin (fmol/ml) | M | 2.76±3.46 | 2.47±3.10 | 2.58±3.64 | 0.80 |
| F | 2.98±3.67 | 2.93±4.06 | 2.76±3.31 | 0.99 | |
| D, rs182052 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 125 | 140 | 50 | |
| F | 52 | 56 | 24 | ||
| NOx (µМ) | M | 32.05±18.01 | 32.05±18.13 | 35.85±26.31 | 0.86 |
| F | 27.56±21.90 | 27.23±20.05 | 30.31±21.58 | 0.87 | |
| Adiponectin (µg/ml) | M | 9.83±6.39 | 8.64±5.75 | 7.68±4.66 | 0.30 |
| F | 11.86±7.79 | 11.51±7.52 | 10.94±7.85 | 0.56 | |
| Endothelin (fmol/ml) | M | 2.65±3.36 | 2.49±2.99 | 3.05±4.21 | 0.96 |
| F | 2.65±3.45 | 3.10±3.93 | 3.17±3.95 | 0.22 | |
| E, rs2241766 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | N | 276 | 38 | 1 | |
| F | 115 | 16 | 1 | ||
| NOx (µМ) | M | 32.78±20.17 | 32.43±15.04 | 29.33 | 0.49 |
| F | 26.41±19.62 | 39.74±28.51 | 31.86 | 0.13 | |
| Adiponectin (µg/ml) | M | 8.86±5.80 | 9.81±6.52 | 4.16 | 0.31 |
| F | 11.38±7.85 | 13.24±6.45 | 11.06 | 0.51 | |
| Endothelin (fmol/ml) | M | 2.64±3.35 | 2.61±3.43 | 4.57 | 0.50 |
| F | 3.05±3.93 | 2.07±1.76 | 2.92 | 0.60 | |
N-values of 0-2 were not analyzed. P-values were calculated using Kruskal-Wallis. SNP, single-nucleotide polymorphism; m, male (sex) or minor allele (genotype); f, female; M, major allele; NOx, nitrate and nitrate.