Table V.
NOx, endothelin-1 and adiponectin levels in male (m) and female (f) patients with various SNP genotypes of the EDN1 gene.
| A, rs2070699SNP | |||||
|---|---|---|---|---|---|
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 80 | 163 | 72 | |
| F | 32 | 64 | 36 | ||
| NOx, µМ | M | 32.09±17.87 | 31.30±17.96 | 36.36±24.24 | 0.58 |
| F | 40.45±30.12 | 23.05±14.95 | 23.44±12.61 | <0.01 | |
| Adiponectin, µg/ml | M | 8.74±4.60 | 9.37±6.65 | 8.26±5.33 | 0.68 |
| F | 11.93±7.66 | 11.37±7.25 | 11.56±8.54 | 0.87 | |
| Endothelin, fmol/ml | M | 2.88±3.53 | 2.44±3.20 | 2.8±3.49 | 0.26 |
| F | 2.21±2.34 | 2.97±3.94 | 3.48±4.26 | 0.27 | |
| B, rs1800542 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 295 | 20 | 0 | |
| F | 116 | 16 | 0 | ||
| NOx, µМ | M | 32.45±19.03 | 35.70±26.90 | - | 0.99 |
| F | 28.16±21.24 | 25.00±19.30 | - | 0.59 | |
| Adiponectin, µg/ml | M | 9.02±6.00 | 7.96±4.04 | - | 0.99 |
| F | 11.75±7.95 | 10.19±5.11 | - | 0.81 | |
| Endothelin, fmol/ml | M | 2.70±3.43 | 1.68±1.31 | - | 0.55 |
| F | 3.02±3.77 | 2.28±3.36 | - | 0.19 | |
| C, rs1800543 SNP | |||||
| Genotype parameter (count or mean ± SD) | |||||
| Parameters | Sex | MM | Mm | mm | P-value |
| N | M | 196 | 105 | 14 | |
| F | 81 | 47 | 4 | ||
| NOx, µМ | M | 31.83±20.45 | 34.02±17.40 | 33.97±23.33 | 0.24 |
| F | 24.38±17.74 | 31.18±21.84 | 52.01±44.01 | 0.02 | |
| Adiponectin, µg/ml | M | 9.02±6.13 | 8.91±5.65 | 8.44±4.54 | 0.98 |
| F | 11.67±7.11 | 11.53±8.92 | 9.68±2.48 | 0.50 | |
| Endothelin, fmol/ml | M | 2.42±3.08 | 2.96±3.79 | 3.33±3.44 | 0.17 |
| F | 2.91±3.87 | 3.12±3.62 | 1.28±0.86 | 0.56 | |
N-values of 0-2 were not analyzed. P-values were calculated using Kruskal-Wallis. SNP, single-nucleotide polymorphism; m, male (sex) or minor allele (genotype); f, female; M, major allele; NOx, nitrate and nitrate.