Table VI.
Summary of significant differences in NOx, endothelin and adiponectin levels in male and female patients with various SNP genotypes of the EDN1 and ADIPOQ genes.
| A, ADIPOQ gene | ||||||
|---|---|---|---|---|---|---|
| SNP | Parameter | Sex | Genotype | N | Mean ± SD | P-value |
| rs17366743 | NOx, µМ | F | MM | 125 | 26.66±19.91 | 0.035 |
| Mm + mm | 7 | 46.17±30.16 | ||||
| Endothelin, fmol/ml | M | MM | 307 | 2.68±4.95 | 0.04 | |
| Mm | 8 | 1.11±0.71 | ||||
| rs266729 | Adiponectin, µg/ml | M | MM + Mm | 282 | 9.21±6.08 | 0.03 |
| mm | 33 | 6.76±3.33 | ||||
| rs182052 | Adiponectin, µg/ml | M | MM | 125 | 9.83±6.39 | 0.03 |
| Mm + mm | 190 | 8.98±5.49 | ||||
| B, EDN1 gene | ||||||
| SNP | Parameter | Sex | Genotype | N | Mean ± SD | P-value |
| rs2070699 | NOx, µМ | F | MM | 32 | 40.45±30.12 | 0.0008 |
| Mm + mm | 100 | 23.17±14.07 | ||||
| rs1800543 | NOx, µМ | F | MM | 81 | 24.38±17.74 | 0.01 |
| Mm + mm | 51 | 32.92±24.37 | ||||
Significance was determined using Mann-Whitney U. SNP, single-nucleotide polymorphism; ADIPOQ, adiponectin; EDN1, endothelin-1; m, male (sex) or minor allele (genotype); f, female; M, major allele; NOx, nitrate and nitrate.