Table VII.
Sex-dependent associations of serum biomarkers, SNPs of the ADIPOQ and EDN1 genes and coronary lesions
| Serum biomarker | Sex | SNP association | Cut-off | Genotype distribution at cut-off | Coronary lesion at cut-off |
|---|---|---|---|---|---|
| NOx, µM | F | rs17366743 | >34 | (Mm + mm) vs. MM | NS |
| ADIPOQ | OR, 5.7; 95% CI, 1.06-30.6; P=0.04 | ||||
| F | rs2070699 EDN1 | >23 | MM vs. (Mm + mm) | NS | |
| OR, 2.67; 95% CI, 1.15-6.26; P=0.023 | |||||
| M | NS | >34 | NS | OR, 2.6; 95% CI, 0.1-7.02; P=0.05 | |
| Endothelin, | M | rs17366743 | <0.6 | Mm vs. MM | OR, 3.4; 95% CI, 1.3-8.8; P=0.013 |
| fmol/ml | ADIPOQ | OR, 8.4: 95% CI, 1.9-36.1; P=0.004 | |||
| F | NS | >1.4 | NS | OR, 2.5; 95% CI, 1.1-5.7; P=0.04 | |
| Adiponectin, | M | rs266729 | <6.2 | mm vs. (MM + Mm) | OR, 2.9; 95% CI, 1.0-8.2; P=0.04 |
| µg/ml | ADIPOQ | OR, 2.02; 95% CI, 0.9-4.1; P=0.05 | |||
| M | rs182052 | <7 | (Mm + mm) vs. MM | OR, 2.9; 95% CI, 1.0-8.2; P=0.04 | |
| ADIPOQ | OR, 1.5; 95% CI, 0.95-2.36; P=0.05 | ||||
| F | NS | NS | NS | NS |
NS, not significant; SNP, single-nucleotide polymorphism; ADIPOQ, adiponectin; EDN1, endothelin-1; m, male (sex) or minor allele (genotype); f, female; M, major allele; NOx, nitrate and nitrate; OR, odds ratio; CI, confidence interval.