Skip to main content
. 2015 Oct 20;2015(10):CD010463. doi: 10.1002/14651858.CD010463.pub2

1. Trials included for N‐based versus P‐based comparison with no information on the elderly.

Non‐platinum single‐agent versus platinum‐based combination treatment
Author, Year Intervention ITT population Median age (range) Elderly
Vansteenkiste 2001 G arm: gemcitabine 1000 mg/m2 D1, D8, D15 q28 days 84 63.7 (55.5–71.9) NA
CV arm: cisplatin 100 mg/m2 + vindesine 3 mg/m2 D1, D15 q 28 days 85 63.1 (54.5–71.7) NA
Le Chevalier 1994 N arm: vinorelbine 30 mg/m2 weekly 206 60 (NA) NA
PN arm: cisplatin 120 mg/m2 D1, D29, then every 6 weeks + vinorelbine 30 mg/m2 weekly 206 59 (NA) NA
PV arm: cisplatin 120 mg/m2 D1, D29, then every 6 weeks + vindesine 3 mg/m2 weekly for 6 weeks, then every 2 weeks 200 59 (NA) NA
Depierre 1994 PV arm: cisplatin 80 mg/m2 on D1 every 3 weeks and vinorelbine 30 mg/m2 weekly 121 59.2 (NA) NA
  V arm: vinorelbine 30 mg/m2 weekly 119 58.8 (NA) NA
Manegold 1998 (Europe) G arm: gemcitabine 1000 mg/m2 D1, D8, D15 q28 days 71 59 (32‐80) NA
EP arm: cisplatin 100 mg/m2 D1 + etoposide 100 mg/m2 D1, D2, D3 q28 days 75 59 (33–78) NA
Manegold 1998 (Taiwan) G arm: gemcitabine 1250 mg/m2 D1, D8, D15 q28 days 27 63 (36–75) NA
EP arm: cisplatin 100 mg/m2 D1 + etoposide 100 mg/m2 D1, D2, D3 q28 days 26 60 (35–75) NA
Perng 1997 G arm: gemcitabine 1250 mg/m2 D1, D8, D15 q28 days 27 63 (36–75) NA
EP arm: cisplatin 80 mg/m2 D1 + etoposide 80 mg/m2 D1, D2, D3 q28 days 26 63 (35‐75) NA
Jeremic 1997 E arm: etoposide 50 mg/m2/d D1 to D21 every 28 days 59 NA NA
EP arm: carboplatin 400 mg/m2 D1 + etoposide 50 mg/m2 D1 to D21 every 28 days 58 NA NA
Rosso 1988 E arm: etoposide 120 mg/m2 D1, D2, D3 q21 days 113 NA NA
EP arm: cisplatin 60 mg/m2 D1, D2 + etoposide 120 mg/m2 D1, D2, D3 103 NA NA
Total   1366   NA
Non‐platinum combination versus platinum combination
Author, Year Intervention ITT population Median age (range) Elderly
Berghmans 2013 GIP arm: gemcitabine 1000 mg/m2 on days 1 and 8 + ifosfamide 3000 mg/m2 on day 1 + cisplatin 50 mg/m2 on day 1 231 58 (29‐78) NA
  DP arm: docetaxel 75 mg/m2 + cisplatin 50 mg/m2 on day 1 233 58 (28‐81) NA
  IG arm: ifosfamide 3000 mg/m2 + gemcitabine 1000 mg/m2 on days 1 and 8 229 59 (30‐84) NA
Saito 2012 CP arm: carboplatin AUC6 plus paclitaxel 200 mg/m2 on day 1, every 3 weeks 41 65 (20‐77) NA
  GV arm: gemcitabine 1000 mg/m2 plus vinorelbine 25 mg/m2 on days 1 and 8, every 3 weeks 43 67 (34‐76) NA
Hsu 2008 GE arm: gemcitabine 1000 mg/m2 on days 1, 8, 15 plus epirubicin 70 mg/m2 43 62.3 (33.9–78.6) NA
  GP arm: gemcitabine 1000 mg/m2 on days 1, 8, 15 plus cisplatin on day 15 42 60.9 (37.6–76) NA
Gricorescu 2007 GV/GI arm: gemcitabine 1000 mg/m2 plus vinorelbine 25 mg/m2 on days 1 and 8 for 2 cycles, followed by gemcitabine 1000 mg/m2 on days 1 and 8 plus ifosfamide 2000 mg/m2 on day 1 for 2 cycles 50 59 (NA) NA
  GP arm: gemcitabine 1250 mg/m2 on days 1 and 8 plus cisplatin 70 mg/m2 on day 1 for 4 cycles 52 56 (NA) NA
Yamamoto 2006 GV arm: gemcitabine 1000 mg/m2 plus vinorelbine 25 mg/m2 on days 1 and 8 64 62 (36‐74) NA
  GC arm: gemcitabine 1000 mg/m2 on days 1 and 8 plus carboplatin AUC5 on day 1 64 60 (30‐74) NA
Katakami 2006 DG arm: docetaxel 60 mg/m2 on day 1 plus gemcitabine 800 mg/m2 on days 1 and 8, every 3 weeks 65 NA NA
  CD arm: cisplatin 80 mg/m2 plus docetaxel 60 mg/m2 on day 1, every 3 weeks. 68 NA NA
Mok 2005 GE arm: gemcitabine 1000 mg/m2 on days 1, 8, and 15 plus etoposide 50 mg/m2 p.o. from day 1 through day 14, every 4 weeks 45 61 (38‐70) NA
  GP arm: cisplatin 75 mg/m2 on day 1 plus gemcitabine 1000 mg/m2 on days 1, 8, and 15, every 4 weeks 44 56 (23‐72) NA
Tan 2005 GV arm: gemcitabine 1000 mg/m2 plus vinorelbine 25 mg/m2 on days 1 and 8, every 3 weeks 157 57 (29–74) NA
  CV arm: carboplatin AUC5 on day 1 plus vinorelbine 30 mg/m2 on days 1 and 8, every 3 weeks 159 60 (30–75) NA
Pujol 2005 GD arm: gemcitabine 1000 mg/m2 days 1 and 8 plus docetaxel 85 mg/m2 day 8, every 3 weeks 155 60 (37–75) NA
  CV arm: cisplatin 100 mg/m2 on day 1 plus vinorelbine 30 mg/m2 on days 1, 8, 15, and 28, every 4 weeks for 6 cycles 156 57 (39–75) NA
Lilenbaum 2005b GV arm: vinorelbine 25 mg/m2 plus gemcitabine 1000 mg/m2 on days 1 and 8, every 3 weeks 82 66 (42–86) NA
  CP arm: paclitaxel 200 mg/m2 plus carboplatin AUC6 on day 1, every 3 weeks 83 63 (38–86) NA
Stathopoulos 2004 PV arm: paclitaxel 135 mg/m2 plus vinorelbine 25 mg/m2 on day 1, every 2 weeks 175 65 (36‐84) NA
  CP arm: carboplatin AUC6 and paclitaxel 175 mg/m2 on day 1, every 3 weeks 185 65 (30‐83) NA
Yamamoto 2004 DI arm: docetaxel 60 mg/m2 on day 8 and irinotecan 60 mg/m2 on days 1 and 8, every 3 weeks 57 60 (42‐77) NA
  CD arm: cisplatin 80 mg/m2 and docetaxel 60 mg/m2 on day 1, every 3 weeks 51 62 (39‐74) NA
Alberola 2003 GV‐VI arm: gemcitabine 1000 mg/m2 and vinorelbine 30 mg/m2 on days 1 and 8, every 3 weeks for 3 cycles, followed by vinorelbine 30 mg/m2 on days 1 and 8 plus ifosfamide 3 g/m2 on day 1 for 3 cycles 187 60 (33‐76) NA
  GC arm: cisplatin 100 mg/m2 on day 1 plus gemcitabine 1250 mg/m2 on days 1 and 8, every 3 weeks 182 59 (39‐74) NA
  CGV arm: cisplatin 100 mg/m2 on day 1 plus gemcitabine 1000 mg/m2 plus vinorelbine 25 mg/m2 on days 1 and 8, every 3 weeks 188 59 (33‐75) NA
Smit 2003 GPac arm: paclitaxel 175 mg/m2 on day 1 plus gemcitabine 1250 mg/m2 on days 1 and 8, every 3 weeks 161 56 (31‐75) NA
  CG arm: cisplatin 80 mg/m2 on day 1 plus gemcitabine 1250 mg/m2 on days 1 and 8, every 3 weeks 160 57 (28‐75) NA
  CP arm: cisplatin 80 mg/m2 plus paclitaxel 175 mg/m2 on day 1, every 3 weeks 159 57 (27‐75) NA
Wachters 2003 GE arm: epirubicin 70 mg/m2 on day 1 plus gemcitabine 1125 mg/m2 on days 1 and 8, every 3 weeks 121 60 (32‐76) NA
  CG arm: cisplatin 80 mg/m2 on day 2 plus gemcitabine 1125 mg/m2 on days 1 and 8, every 3 weeks 119 60 (29‐80) NA
Sculier 2002 IG arm: ifosfamide 4500 mg/m2 on day 1 plus gemcitabine 1000 mg/m2 on days 1, 8, and 15, every 4 weeks 94 52 > 60 years old NA
  CCI arm: cisplatin 60 mg/m2 and carboplatin AUC3 and ifosfamide 4500 mg/m2 over 18‐hour i.v. infusion on day 1, every 4 weeks 94 45 > 60 years old NA
  CCG arm: cisplatin 60 mg/m2 on day 1 plus carboplatin AUC3 on day 1 and gemcitabine 1000 mg/m2 on days 1, 8, and 15, every 4 weeks 92 52 > 60 years old NA
Chen 2002 PG arm: paclitaxel 175 mg/m2 on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8, every 3 weeks 45 67 (35‐80) NA
  CP arm: carboplatin AUC7 on day 1 plus paclitaxel 175 mg/m2 on day 1, every 3 weeks 45 64 (37‐77) NA
Buccheri 1997 MACC arm: methotrexate 40 mg/m2, doxorubicin 40 mg/m2 i.v., cyclophosphamide 400 mg/m2 i.v. infusion, and lomustine 30 mg/m2 per os on day 1, every 3 weeks 78 64 (NA) NA
  MVP arm: mitomycin C 10 mg/m2, vinblastine 6 mg/m2, and cisplatin 40 mg/m2 i.v. infusions on day 1, every 3 weeks 78 65 (NA) NA
Hara 1990 MCT arm: mitomycin C 4 mg/body i.v. infusion and cytosine arabinoside 30 mg/body on days 1, 4, 14, 21, and 28 and tegafur 600 mg orally every day 67 63 (37‐75) NA
  CAPM arm: cyclophosphamide 400 mg/m2 i.v. infusion on day 1, Adriamycin 30 mg/m2 i.v. infusion on day 1, cisplatin 60 mg/m2 i.v. infusion on day 1, and mitomycin C 3 mg/m2 i.v. infusion on day 1 69 60 (27‐75) NA
Total   5040