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. 2015 Oct 20;2015(10):CD010463. doi: 10.1002/14651858.CD010463.pub2

Comparison 5. Outcome analysis by type of trial (elderly specific vs elderly subgroup).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Overall survival 13   Hazard Ratio (Fixed, 95% CI) 0.76 [0.69, 0.85]
1.1 Elderly specific 4   Hazard Ratio (Fixed, 95% CI) 0.74 [0.63, 0.86]
1.2 Elderly subgroup analysis 9   Hazard Ratio (Fixed, 95% CI) 0.79 [0.68, 0.91]
2 1‐Year overall survival 13 1695 Risk Ratio (M‐H, Fixed, 95% CI) 0.89 [0.82, 0.96]
2.1 Elderly specific 5 981 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.75, 0.93]
2.2 Elderly subgroup 8 714 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.86, 1.08]
3 Progression‐free survival 9   Hazard Ratio (Random, 95% CI) 0.76 [0.61, 0.93]
3.1 Elderly specific 3   Hazard Ratio (Random, 95% CI) 0.67 [0.44, 1.02]
3.2 Elderly subgroup 6   Hazard Ratio (Random, 95% CI) 0.83 [0.69, 1.00]
4 Objective response rate 11 1432 Risk Ratio (M‐H, Fixed, 95% CI) 1.57 [1.32, 1.85]
4.1 Elderly specific 4 808 Risk Ratio (M‐H, Fixed, 95% CI) 1.76 [1.37, 2.26]
4.2 Elderly subgroup 7 624 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [1.12, 1.76]
5 Anemia 11 1437 Risk Ratio (M‐H, Fixed, 95% CI) 2.53 [1.70, 3.76]
5.1 Elderly specific 5 956 Risk Ratio (M‐H, Fixed, 95% CI) 2.85 [1.77, 4.57]
5.2 Elderly subgroup 6 481 Risk Ratio (M‐H, Fixed, 95% CI) 1.88 [0.89, 3.94]
6 Neutropenia 11 1422 Risk Ratio (M‐H, Random, 95% CI) 1.49 [0.77, 2.85]
6.1 Elderly specific 5 955 Risk Ratio (M‐H, Random, 95% CI) 1.43 [0.27, 7.50]
6.2 Elderly subgroup 6 467 Risk Ratio (M‐H, Random, 95% CI) 1.25 [0.88, 1.77]
7 Thrombocytopenia 9 1260 Risk Ratio (M‐H, Fixed, 95% CI) 3.59 [2.22, 5.82]
7.1 Elderly specific 3 779 Risk Ratio (M‐H, Fixed, 95% CI) 3.96 [1.86, 8.42]
7.2 Elderly subgroup 6 481 Risk Ratio (M‐H, Fixed, 95% CI) 3.36 [1.80, 6.29]
8 Febrile neutropenia 8 1215 Risk Ratio (M‐H, Random, 95% CI) 1.58 [0.56, 4.50]
8.1 Elderly specific 3 777 Risk Ratio (M‐H, Random, 95% CI) 0.64 [0.02, 16.48]
8.2 Elderly subgroup 5 438 Risk Ratio (M‐H, Random, 95% CI) 1.77 [0.85, 3.70]
9 Fatigue 7 1150 Risk Ratio (M‐H, Fixed, 95% CI) 1.56 [1.02, 2.38]
9.1 Elderly specific 2 712 Risk Ratio (M‐H, Fixed, 95% CI) 1.78 [1.00, 3.17]
9.2 Elderly subgroup 5 438 Risk Ratio (M‐H, Fixed, 95% CI) 1.31 [0.69, 2.46]
10 Emesis 8 1193 Risk Ratio (M‐H, Fixed, 95% CI) 3.64 [1.82, 7.29]
10.1 Elderly specific 2 712 Risk Ratio (M‐H, Fixed, 95% CI) 3.71 [1.04, 13.18]
10.2 Elderly subgroup 6 481 Risk Ratio (M‐H, Fixed, 95% CI) 3.61 [1.57, 8.29]
11 Diarrhea 7 1075 Risk Ratio (M‐H, Fixed, 95% CI) 1.75 [0.91, 3.38]
11.1 Elderly specific 2 712 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.36, 2.87]
11.2 Elderly subgroup 5 363 Risk Ratio (M‐H, Fixed, 95% CI) 2.53 [1.05, 6.12]