Comparison 5. Outcome analysis by type of trial (elderly specific vs elderly subgroup).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	13		Hazard Ratio (Fixed, 95% CI)	0.76 [0.69, 0.85]
1.1 Elderly specific	4		Hazard Ratio (Fixed, 95% CI)	0.74 [0.63, 0.86]
1.2 Elderly subgroup analysis	9		Hazard Ratio (Fixed, 95% CI)	0.79 [0.68, 0.91]
2 1‐Year overall survival	13	1695	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.82, 0.96]
2.1 Elderly specific	5	981	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.75, 0.93]
2.2 Elderly subgroup	8	714	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.86, 1.08]
3 Progression‐free survival	9		Hazard Ratio (Random, 95% CI)	0.76 [0.61, 0.93]
3.1 Elderly specific	3		Hazard Ratio (Random, 95% CI)	0.67 [0.44, 1.02]
3.2 Elderly subgroup	6		Hazard Ratio (Random, 95% CI)	0.83 [0.69, 1.00]
4 Objective response rate	11	1432	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [1.32, 1.85]
4.1 Elderly specific	4	808	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [1.37, 2.26]
4.2 Elderly subgroup	7	624	Risk Ratio (M‐H, Fixed, 95% CI)	1.41 [1.12, 1.76]
5 Anemia	11	1437	Risk Ratio (M‐H, Fixed, 95% CI)	2.53 [1.70, 3.76]
5.1 Elderly specific	5	956	Risk Ratio (M‐H, Fixed, 95% CI)	2.85 [1.77, 4.57]
5.2 Elderly subgroup	6	481	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [0.89, 3.94]
6 Neutropenia	11	1422	Risk Ratio (M‐H, Random, 95% CI)	1.49 [0.77, 2.85]
6.1 Elderly specific	5	955	Risk Ratio (M‐H, Random, 95% CI)	1.43 [0.27, 7.50]
6.2 Elderly subgroup	6	467	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.88, 1.77]
7 Thrombocytopenia	9	1260	Risk Ratio (M‐H, Fixed, 95% CI)	3.59 [2.22, 5.82]
7.1 Elderly specific	3	779	Risk Ratio (M‐H, Fixed, 95% CI)	3.96 [1.86, 8.42]
7.2 Elderly subgroup	6	481	Risk Ratio (M‐H, Fixed, 95% CI)	3.36 [1.80, 6.29]
8 Febrile neutropenia	8	1215	Risk Ratio (M‐H, Random, 95% CI)	1.58 [0.56, 4.50]
8.1 Elderly specific	3	777	Risk Ratio (M‐H, Random, 95% CI)	0.64 [0.02, 16.48]
8.2 Elderly subgroup	5	438	Risk Ratio (M‐H, Random, 95% CI)	1.77 [0.85, 3.70]
9 Fatigue	7	1150	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [1.02, 2.38]
9.1 Elderly specific	2	712	Risk Ratio (M‐H, Fixed, 95% CI)	1.78 [1.00, 3.17]
9.2 Elderly subgroup	5	438	Risk Ratio (M‐H, Fixed, 95% CI)	1.31 [0.69, 2.46]
10 Emesis	8	1193	Risk Ratio (M‐H, Fixed, 95% CI)	3.64 [1.82, 7.29]
10.1 Elderly specific	2	712	Risk Ratio (M‐H, Fixed, 95% CI)	3.71 [1.04, 13.18]
10.2 Elderly subgroup	6	481	Risk Ratio (M‐H, Fixed, 95% CI)	3.61 [1.57, 8.29]
11 Diarrhea	7	1075	Risk Ratio (M‐H, Fixed, 95% CI)	1.75 [0.91, 3.38]
11.1 Elderly specific	2	712	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.36, 2.87]
11.2 Elderly subgroup	5	363	Risk Ratio (M‐H, Fixed, 95% CI)	2.53 [1.05, 6.12]