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. 2019 Sep 18;6:300. doi: 10.3389/fvets.2019.00300

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Copyright © 2019 Setthawongsin, Teewasutrakul, Tangkawattana, Techangamsuwan and Rungsipipat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The tumor relative volume, fibrosis area and TIL/CTVT ratio of CTVT samples before treatment (wk0) and during treatment (wk1–2 PT). The tumor relative volume had a decreasing trend (A). On the other hand, the areas of fibrosis had the increasing trend significantly (B). The TIL/CTVT ratio had a trend of increasing due to the increasing of TILs and decreasing of CTVT cells (C) [Friedman repeated measures analysis of variance and Wilcox Signed-Rank test was used to determine the significance of differentiation before (wk0) and during treatment (wk1 and wk2) in each group, ^*p < 0.05].