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. 2019 Sep 18;6:300. doi: 10.3389/fvets.2019.00300

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Copyright © 2019 Setthawongsin, Teewasutrakul, Tangkawattana, Techangamsuwan and Rungsipipat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ki-67 proliferative index (PI) on CTVT sample before treatment (wk0) and during treatment (wk1–2). Ki-67 PI of conventional protocol revealed variable values, on the other hand, modified combination protocol shown the decreasing trend. Moreover, Ki-67 PI of modified combination protocol in wk-2 PT was lower than the conventional protocol significantly (a = 0.024) (A). The treatment time of modified combination protocol was shorter than conventional protocol significantly (b = 0.019) (B) (Mann-Whitney U-test was used to determine the significance of differentiation between the conventional and modified combination chemotherapeutic protocols, ^{a, b}p < 0.05).