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. 2019 Sep 18;6:300. doi: 10.3389/fvets.2019.00300

Figure 4.

Figure 4

Relative mRNA expression of Bcl-2 (A) and Bax (B) in CTVT dogs before treatment (wk0) and during treatment (wk1–2 PT). Relative mRNA expression of Bcl-2 in wk1 lower than wk0 in CTVT dogs treated with VCR. In addition, relative mRNA expression of Bax during treatment lower than wk0 in CTVT dogs treated with VCR-LAP [Friedman repeated measures analysis of variance and Wilcox Signed-Rank test was used to determine the significance of differentiation before (wk0) and during treatment (wk1 and wk2) in each group, *p < 0.05]. Relative mRNA expression of Bcl-2 in CTVT dogs treated with VCR lower than VCR-LAP in wk1 significantly (Mann-Whitney U-test was used to determine the significance of differentiation between the conventional and modified combination chemotherapeutic protocols, ap < 0.05).