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. 2019 Sep 18;6:300. doi: 10.3389/fvets.2019.00300

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Copyright © 2019 Setthawongsin, Teewasutrakul, Tangkawattana, Techangamsuwan and Rungsipipat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of the apoptotic protein Bcl-2 (A) and Bax (B) in CTVT dogs before treatment (wk0) and during treatment (wk1–2 PT). BCL-2 expression (VCR) in wk 2 lower than wk0 significantly. Moreover, BAX expression (VCR-LAP) after treatment lower than before treatment significantly [Friedman repeated measures analysis of variance and Wilcox Signed-Rank test was used to determine the significance of differentiation before (wk0) and during treatment (wk1 and wk2) in each group, ^*p < 0.05]. BAX protein expression of the VCR-LAP protocol was significantly higher than the VCR protocol at wk2-PT (Mann-Whitney U-test was used to determine the significance of differentiation between the conventional and modified combination chemotherapeutic protocols, ^ap < 0.05).