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. 2019 Sep 18;6:300. doi: 10.3389/fvets.2019.00300

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Copyright © 2019 Setthawongsin, Teewasutrakul, Tangkawattana, Techangamsuwan and Rungsipipat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative mRNA expression of the ABC transporters ABCB1 (A) and ABCG2 (B) in CTVT dogs before treatment (wk0) and during treatment (wk1–2 PT). Relative mRNA expression of ABCG2 of CTVT dogs treated with VCR lower than VCR-LAP in wk2 significantly (Mann-Whitney U-test was used to determine the significance of differentiation between the conventional and modified combination chemotherapeutic protocols, ^ap < 0.05).