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. 2019 Sep 18;10:875. doi: 10.3389/fgene.2019.00875

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Copyright © 2019 Xiao, Li, Shafique, Zhao, Su, Zhang, Cui, Liu and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple-sequence alignment of rabbit MC1R gene and protein structures. (A) Multiple-exon-sequence alignment of MC1R gene of Gray Giant rabbit (GR), New Zealand White rabbit (WR), Checkered Giant rabbit (CR), Lianshan black rabbit (BR), Fujian yellow rabbit (YR), Thrianta rabbit (GenBank: FN658678.1), and Japanese brindling (GenBank: FN658679.1).The six nucleotides in blue and green boxes are those that are deleted in the rabbit MC1R gene c.125-130del6 and c.281-286del6 alleles, respectively. The 30 nucleotides in the red box are those deleted in the c.304-333del30 alleles. (B) Spontaneous mutations carried by rabbits of different breeds and coat colors. The MC1R gene of GR are wild-type alleles which encoded 317 amino acids. The two amino acids in blue circle is those deleted in the c.125-130del6 allele (e^J), carried by Japanese brindling rabbit. The two amino acids in green circle are those deleted in the c.125-130del6 alleles (E^D), carried by WR, CR, and BR. And the 10 amino acids in red circle are those that are deleted in the c.304-333del30 alleles (e), carried by YR and Thrianta rabbit (the diagram of amino acid composition of rabbit mature MC1R protein with seven transmembrane domains was modified from Wolf Horrell et al. (2016).