Table 5.

Studies on different sources and dosing of UM206: echocardiographic parameters (EDV and ESV), hemodynamic characteristics determination (dP/dt max and dP/dt min), and heart and lung weight measurements.

	Study E		Study F		Study G
	Pepscan 6 μg/kg/day		Chempep 6 μg/kg/day		Pepscan 150 μg/kg/day
	Saline	UM206	Saline	UM206	Saline	UM206
EDV (cm3)	0.187 ± 0.011	0.182 ± 0.007	0.142 ± 0.008	0.137 ± 0.020	0.194 ± 0.020	0.190 ± 0.019
ESV (cm3)	0.145 ± 0.012	0.144 ± 0.008	0.109 ± 0.010	0.115 ± 0.026	0.152 ± 0.021	0.148 ± 0.022
dP/dt max (mmHg/sec)†	3915 ± 587	3349 ± 622	2201 ± 432	4039 ± 1711	3150 ± 561	3826 ± 446
dP/dt min (mmHg/sec)†	−1941 ± 302	−1841 ± 335	−924 ± 232	−1861 ± 559	−1537 ± 356	−1767 ± 247
HW/BW	0.0044 ± 0.0001	0.0043 ± 0.0001	0.0051 ± 0.0004	0.0053 ± 0.0005	0.0048 ± 0.0003	0.0045 ± 0.0001
LW/BW	0.0057 ± 0.0005	0.0049 ± 0.0002	0.0070 ± 0.0019	0.0080 ± 0.0022	0.0065 ± 0.0011	0.0071 ± 0.0011

The dP/dt max^† and dP/dt min^† data represent the effect of dobutamine on the dP/dt corrected for the baseline (dP/dt max or min value minus the dP/dt baseline value respectively). EDV, end diastolic volume; ESV, end systolic volume; HW/BW, heart weight to body weight ration; LW/BW, lung weight to body weight ratio. Data are presented as mean ± SEM.