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. 2019 Sep 18;13:421. doi: 10.3389/fncel.2019.00421

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Copyright © 2019 Mosley, Lu, Olson, Machhi, Yan, Namminga, Smith, Shandler and Gendelman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VIPR2 agonist diminishes microglial response to α-Syn overexpression. Sprague-Dawley rats were treated as sham control (n = 5) or stereotactically injected with AAV-GFP (N = 6) or AAV-α-Syn vector (n = 6–7/group). AAV-α-Syn-treated rats started the same regimen as in Figure 4 of vehicle (0) (n = 7) or LBT-3627 administered at 0.6, 2.0, or 6.0 mg/kg (n = 6/group). On day 28 after infection, brains were obtained and sections of midbrain were stained for expression of Iba1 by microglia. Numbers of Iba1⁺ amoeboid microglia were determined by stereological analysis. Means and SEM were determined from 5 to 7 rats/group. Significant differences were assessed by one-way ANOVA and Newman-Keuls post hoc tests. P ≤ 0.05 compared to treatments as ^asham controls, ^bAAV-GFP, or AAV-α-Syn and ^cPBS. Scale bar, 40 μm.