Table 2.
Total 84 synaptic plasticity associated genes were classified as 10 groups according to the functions.
| Function | Gene symbol |
|---|---|
| Imediate-early response genes (IEGs) | Arc, Bdnf, Cebpb, Cebpd, Creb1, Crem, Egr1, Egr2, Egr3, Egr4, Fos, Homer1, Jun, Junb, Klf10, Mmp9 (Gelatinase B), Nfkb1, Nfkbib (Trip9), Ngf, Nptx2, Nr4a1, Ntf3, Pcdh8, Pim1, Plat (tPA), Rela, Rgs2, Rheb, Srf, Tnf |
| Long term potentiation (LTP) | Adcy1, Adcy8, Bdnf, Camk2a, Camk2g, Cdh2 (N-cadherin), Cnr1, Gabra5, Gnai1, Gria1, Gria2, Grin1, Grin2a, Grin2b, Grin2c, Grin2d, Mapk1, Mmp9 (Gelatinase B), Ntf5, Ntrk2, Plcg1, Ppp1ca, Ppp1cc, Ppp3ca, Prkca, Prkcc, Rab3a, Ywhaq |
| Long term depression (LTD) | Gnai1, Gria1, Gria2, Gria3, Gria4, Grip1, Grm1, Grm2, Igf1, Mapk1, Nos1, Ngfr, Pick1, Plat (tPA), Ppp1ca, Ppp1cc, Ppp1r14a (Cpi-17), Ppp2ca, Ppp3ca, Prkca, Prkg1 |
| Cell adhesion | Adam10, Cdh2 (N-cadherin), Grin2a, Grin2b, Ncam1, Pcdh8, Ppp2ca, Reln, Tnf |
| Extracellular matrix & proteolytic processing (EMPP) | Adam10, Mmp9 (Gelatinase B), Plat (tPA), Reln, Timp1 |
| CREB cofactors | Akt1, Camk2g, Grin1, Grin2a, Grin2b, Grin2c, Grin2d, Mapk1 (Erk2), Ppp1ca, Ppp1cc |
| Neuronal receptors (NR) | Ephb2, Gabra5, Gria1, Gria2, Gria3, Gria4, Grin1, Grin2a, Grin2b, Grin2c, Grin2d, Grm1, Grm2, Grm3, Grm4, Grm5, Grm7, Grm8, Ntrk2 |
| Postsynaptic density (PSD) | Adam10, Arc, Dlg4 (Psd95), Gria1, Gria3, Gria4, Grin1, Grin2a, Grin2b, Grin2c, Grm1, Grm3, Homer1, Pick1, Synpo |
| Late response genes | Inhba, Synpo |
| Others | Kif17, Sirt1 |
Underline: fold changes >1;5; P < 0.05.