Table 1.
The summary of ncRNA that regulate PDCD4 in different cancers and inflammatory disorders.
| Cancer | ncRNA | Functional responses and targets | References |
|---|---|---|---|
| Laryngeal cancer | miR-503 | miR-503 inhibits apoptosis by directly targeting PDCD4 | (39) |
| miR-744-3p | miR-744-3p regulates PDCD4 to reduce AKT and NF-κB activation as well as MMP-9 expression | (40) | |
| Gastric cancer | miR-23a/b | miR-23a/b promotes tumor growth and suppress apoptosis by targeting PDCD4 | (41) |
| miR-208a-3p | miR-208a-3p suppresses cell apoptosis by targeting PDCD4 | (42) | |
| miR-93 | miR-93 functions as an oncomiR for the downregulation of PDCD4 | (43) | |
| miR-196a2 | miR-196a2 inhibits apoptosis by directly targeting PDCD4 | (44) | |
| Colorectal cancer | miR-1260b | miR-1260b inhibitor enhances the chemosensitivity 5-FU due to downregulation of PDCD4 | (45) |
| miR-181b | Activation of IL-6/STAT3 suppressed PDCD4 by upregulating miR-181b | (46) | |
| Cervical cancer | miR-150 | miR-150 functions as a tumor promoter in reducing chemosensitivity and promoting invasiveness via targeting PDCD4 | (47) |
| Breast cancer | miR-421 | PDCD4 is a direct target gene of miR-421 | (10) |
| miR-183-5p | Inhibition of miR-183-5p could repress the progression of breast cancer through restoring PDCD4 levels | (48) | |
| Melanoma | CASC15 | CASC15 acts as an oncogene by negatively regulating PDCD4 expression via recruiting EZH2 and subsequently increasing H3K27me3 level | (49) |
| miR-150 | Knockdown of miR-150 enhanced cell apoptosis via direct targeting of PDCD4 | (50) | |
| Osteosarcoma | miR-433 | miR-433 suppresses the expression of PDCD4 | (51) |
| Lung cancer | miR-155 | miR-155 exerts an onco- genic role in NSCLC by directly targeting PDCD4 | (52) |
| Liver cancer | miR-93 | miR-93 dramatically promoted HCC invasion and metastasis by EMT via targeting PDCD4 | (53) |
| Glioblastoma | miR-503 | microRNA-503 increases proliferation of glioblastoma cells and inhibits apoptosis by directly targeting PDCD4 | (54) |
| Osteosarcoma | XIST/miR-21-5p | lncRNA-XIST acts as a miRNA sponge, impedes miR-21-5p to maintain the expression of PDCD4 | (55) |
| Colorectal cancer | Linc00472/miR-196a | Linc00472 suppressed proliferation and induced apoptosis through up-regulating PDCD4 by decoying miR-196a | (56) |
| Esophageal carcinoma | TUG1 | TUG1 suppressed PDCD4 expression by recruiting EZH2 to the promoter region of PDCD4 and increasing H3K27me3 level in ESCC cells | (57) |
| CASC9 | lncRNA CASC9 functions as an oncogene by negatively regulating PDCD4 expression through recruiting EZH2 and subsequently altering H3K27me3 level | (58) | |
| Glioma | HOTAIR | Suppression of PDCD4 mediated by HOTAIR inhibits glioma cell proliferation and invasion in a PRC2-dependent manner | (59) |