Fig. 3.

Mutation profiling of normal mucosa, cancerous tissues, and ELA in ten cases. The upper panel shows the number of somatic mutations in each tissue type for each of the ten cases. The lower panel shows the mutation pattern in each mutated gene in each tissue from the ten cases. Red cells represent Category I mutation (frameshift indels or nonsense mutations), yellow cells represent Category II mutations (missense mutations), and gray cells represent Category III mutations (synonymous mutations or mutations located within introns). Asterisks represent mutations found in the COSMIC database