Table 4.
Comparison of optimal PPVs in the condition of 100% sensitivity for chain acyl-CoA dehydrogenase deficiencies between new ratio and used indicators using initial screening values in the testing data.
| TP | FP | PPV | x2 | p | |
|---|---|---|---|---|---|
| SCAD deficiency | |||||
| C4/C5DC+C6-OH | 11 | 4 | 73.3% | – | – |
| C4 | 11 | 348 | 3.1% | 344.00a | <0.001a |
| (C4, C4/C2) | 11 | 39 | 22.0% | 28.49a | <0.001a |
| MCAD deficiency | |||||
| C8/C14:1 | 4 | 18 | 18.2% | – | – |
| C8 | 4 | 411 | 1.0% | 372.37b | <0.001b |
| (C6, C8, C8/C2, C4DC+C5-OH/C8:1) | 4 | 115 | 3.4% | 81.00b | <0.001b |
| VLCAD deficiency | |||||
| C14:1/C16-OH | 5 | 0 | 100.0% | – | – |
| C14:1 | 5 | 8 | 38.5% | 8.00c | 0.005c |
| (C14:1, C14:1/C16, C14:1/C2) | 5 | 0 | 100.0% | –c | –c |
SCAD, short chain acyl-CoA hydrogenase; MCAD, medium chain acyl-CoA hydrogenase; VLCAD, very long chain acyl-CoA hydrogenase; TP, true positive; FP, false positive; PPV, positive predictive value.
aCompared with C4/C5DC+C6-OH; bcompared with C8/C14:1; ccompared with C14:1/C16-OH.