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Proposed mechanism for HEAL- and FUS-mediated regulation of HIV-1 replication. HIV-1 infection enhances expression of HEAL, which interacts with FUS protein and increases HEAL-FUS binding at the HIV promoter. HEAL-FUS complex recruits histone acetyltransferase p300 to enhance H3K27ac modification, leading to P-TEFb enrichment on the HIV promoter and processive transcription. See the text for details.
