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. 2019 Sep 18;10:1043. doi: 10.3389/fphar.2019.01043

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Copyright © 2019 Chinak, Golubitskaya, Pyshnaya, Stepanov, Zhuravlev, Richter and Koval

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic activity of non-coding artificial analogue of U25 box C/D snoRNA in A549 cells. Cells were treated with RL2:snoRNA complexes, and after 48 h of incubation, cells viability was analyzed by MTT. LF—Lipofectamine 3000. (A) Comparison with LF-dependent delivery. *P < 0.05 compared with control (free RNA); (B) Concentration-response curves for the different RL2 concentration. The data are representative of three independent repeats. *P < 0.05 compared with control (only RL2 treatment).