Table 2.
Unadjusted and adjusted risk estimates for prostate cancer.
| Outcome | Fathers conceiving by IVF compared with natural conception | Fathers conceiving by ICSI compared with natural conception | |||
|---|---|---|---|---|---|
| Risk estimate (95% CI) | P value | Risk estimate (95% CI) | P value | ||
| Prostate cancer: | |||||
| Unadjusted hazard ratio | 2.09 (1.66 to 2.62) | <0.001 | 3.12 (2.38 to 4.08) | <0.001 | |
| Adjusted hazard ratio | 1.33 (1.06 to 1.66) | 0.02 | 1.64 (1.25 to 2.15) | <0.001 | |
| Early onset prostate cancer: | |||||
| Unadjusted hazard ratio | 2.93 (2.12 to 4.05) | <0.001 | 3.66 (2.46 to 5.44) | <0.001 | |
| Adjusted hazard ratio | 1.51 (1.09 to 2.08) | 0.01 | 1.86 (1.25 to 2.77) | 0.002 | |
| Androgen deprivation therapy: | |||||
| Unadjusted odds ratio | 0.89 (0.42 to 1.87) | 0.76 | 1.59 (0.79 to 3.19) | 0.19 | |
| Adjusted odds ratio | 0.99 (0.47 to 2.10) | 0.98 | 1.91 (0.94 to 3.88) | 0.07 | |
ICSI=intracytoplasmic sperm injection; IVF=in vitro fertilisation.