Figure 2.

Pharmacological inhibition of Cysltr1 protected against APAP-induced hepatotoxicity. (A). Schedule of montelukast administration in APAP-overdose mice. Montelukast (3 mg/kg) or vehicle were administered 1 h after APAP treatment. At 12 h after APAP administration, mice were killed, and blood and liver tissues were collected. Serum levels of ALT (B) and AST (C). (D) H&E staining of liver sections from APAP- or saline-treated mice. APAP-induced centrilobular necrosis was indicated by dotted line. (E) Quantification of liver necrosis area. Data are mean ± SEM, n = 5 for saline groups, n = 7 for APAP groups, **p < 0.01.