TABLE 3.
RP2 (μg/mL) |
Mutation frequency |
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Ciprofloxacin |
Tetracycline |
Erythromycin |
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2 MIC | 4 MIC | 8 MIC | 16 MIC | 2 MIC | 4 MIC | 8 MIC | 16 MIC | 2 MIC | 4 MIC | 8 MIC | 16 MIC | |
0 | 5.5 × 10–8 | 3.9 × 10–8 | 1.8 × 10–8 | <10–8 | 5.6 × 10–8 | 4.8 × 10–8 | 2.5 × 10–8 | <10–8 | 6.9 × 10–8 | 5.1 × 10–8 | 3.5 × 10–8 | <10–8 |
16 | 3.6 × 10–8 | 1.5 × 10–8 | <10–8 | <10–8 | 2.7 × 10–8 | 1.3 × 10–8 | <10–8 | <10–8 | 3.6 × 10–8 | 1.4 × 10–8 | <10–8 | <10–8 |
32 | <10–8 | <10–8 | <10–8 | <10–8 | <10–8 | <10–8 | <10–8 | <10–8 | 1.2 × 10–8 | <10–8 | <10–8 | <10–8 |
The results presented correspond to the average of three independent assays.