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. 2019 Sep 18;10:1051. doi: 10.3389/fphar.2019.01051

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Copyright © 2019 Boknik, Drzewiecki, Eskandar, Gergs, Hofmann, Treede, Grote-Wessels, Fabritz, Kirchhof, Fortmüller, Müller, Schmitz, Zimmermann, Kirchhefer and Neumann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A_2A-AR increased the incidence of arrhythmias in vitro. In isolated spontaneously beating right atrial preparations (RA), we noted a higher propensity to arrhythmias in A_2A-TG than in WT under basal conditions (A). Also, in isolated perfused hearts, we noted more atrial arrhythmias in A_2A-TG than in WT (B). ^★p < 0.05 vs. WT (χ²-test).