Table 1.
Echocardiographic measurements under basal conditions (BASE) and after application of isoproterenol (ISO).
| Parameters | BASE | ISO | ||
|---|---|---|---|---|
| A2A-TG | WT | A2A-TG | WT | |
| Age (weeks) | 15 ± 0.66 | 14 ± 0.74 | 15 ± 0.66 | 14 ± 0.74 |
| N | 15 | 15 | 15 | 15 |
| HR (bpm) | 467 ± 8 | 453 ± 9 | 635 ± 8 | 635 ± 8 |
| LA (mm) | 1.23 ± 0.03* | 1.08 ± 0.01 | 1.21 ± 0.03* | 1.07 ± 0.01 |
| LVEDd (mm) | 3.78 ± 0.08 | 3.58 ± 0.07 | 3.18 ± 0.12* | 2.87 ± 0.06 |
| EDV (µl) | 61.79 ± 2.95 | 54.15 ± 2.50 | 41.50 ± 3.52* | 31.80 ± 1.77 |
| FS (%) | 33.40 ± 1.59 | 36.45 ± 0.88 | 45.24 ± 2.05* | 53.67 ± 1.01 |
| LV/BW ratio | 3.52 ± 0.16 | 3.20 ± 0.12 | 3.30 ± 0.31 | 3.05 ± 0.12 |
| MV PG max (mmHg) | 2.69 ± 0.35 | 1.81 ± 0.35 | 3.84 ± 0.42 | 3.23 ± 0.43 |
| MV E (cm/s) | 80.21 ± 4.66* | 66.50 ± 2.72 | 96.08 ± 5.28 | 87.49 ± 5.46 |
| MV A (cm/s) | 52.72 ± 3.80* | 41.07 ± 2.31 | 67.03 ± 5.87 | 65.18 ± 5.87 |
| MV E/A | 1.55 ± 0.05 | 1.66 ± 0.05 | 1.49 ± 0.07 | 1.40 ± 0.06 |
Data are mean values ± SEM. HR, heart rate; LA, left atrial diastolic diameter; LVEDd, left ventricular enddiastolic diameter; EDV, left ventricular enddiastolic volume; FS, fractional shortening; LV/BW ratio, calculated LV weight in relationship to mouse body weight; MV PG max, mitral valve maximal pressure gradient; MV E and MV A, first and second peak of mitral valve flow velocity. *p < 0.05 A2A-TG vs. WT (same treatment group).