Table 4.
Absolute Measures of Association Between BMI and Atrial Fibrillation Using Parametric g‐Formula
| Intervention | Comparator | Difference in Risk (%) or RMST (Months) | |
|---|---|---|---|
| 10 y | |||
| Nonobese vs obese | |||
| Risk, % | 2.69 (1.35–4.03) | 3.49 (1.97–5.02) | −0.81 (−2.21 to 0.59) |
| RMST, y | 9.88 (9.79–9.96) | 9.86 (9.78–9.93) | 0.24 (−0.94 to 1.42) |
| Nonobese vs natural course | |||
| Risk, % | 2.69 (1.34–4.04) | 2.74 (1.65–3.83) | −0.05 (−0.92 to 0.82) |
| RMST, y | 9.88 (9.78–9.97) | 9.88 (9.83–9.93) | −0.09 (−1.00 to 0.82) |
| 10% decrease in BMI per year vs natural course | |||
| Risk, % | 2.71 (1.63–3.79) | 2.75 (1.66–3.84) | −0.04 (−0.19 to 0.11) |
| RMST, y | 9.88 (9.83–9.93) | 9.88 (9.83–9.93) | 0.01 (−0.06 to 0.07) |
| 20 y | |||
| Nonobese vs obese | |||
| Risk, % | 9.94 (8.48–11.40) | 13.27 (11.26–15.28) | −3.33 (−5.48 to −1.18) |
| RMST, y | 19.22 (19.01–19.43) | 19.03 (18.86–19.20) | 2.25 (−0.66 to 5.16) |
| Nonobese vs natural course | |||
| Risk, % | 9.95 (8.50–11.40) | 10.84 (9.73–11.96) | −0.90 (−1.97 to 0.18) |
| RMST, y | 19.22 (19.01–19.43) | 19.20 (19.10–19.29) | 0.30 (−1.96 to 2.55) |
| 10% decrease in BMI per year vs natural course | |||
| Risk, % | 10.45 (9.31–11.60) | 10.88 (9.75–12.00) | −0.43 (−0.86 to 0.00) |
| RMST, y | 19.21 (19.12–19.31) | 19.19 (19.10–19.29) | 0.23 (−0.11 to 0.57) |
Numbers are estimates and 95% CIs, obtained with 500 bootstrap samples. Analyses are adjusted for SBP, DBP, current smoking status, use of hypertension medication, diabetes mellitus status, history of heart failure, and history of myocardial infarction. BMI indicates body mass index; DBP, diastolic blood pressure; RMST, restricted mean survival time; SBP, systolic blood pressure.