Table 3.

Location, treatment, survival and molecular charachteristics of 24 patients with brain metastases from PDAC

Pt	Molecular	Site of BM	Surgery Y/N	RT	LMD	BM Survival (days)	1ST Line chemo.	OS advanced disease (months)
1	KRAS G12D	Cerebellum, Right frontal	N	WBRT	N	2	Cisplatin + gemcitabine	82
2	KRAS Q61K, MYC Amp, FGFR1 Amp	Right occipital, Right frontal	N	WBRT	N	77	FOLFIRINOX	3
3	KRAS G12D, TP53 R273H	Right frontal	Y	WBRT	Y	52	Gemcitabine plus nab-paclitaxel	10
4	KRAS G12V BRCA2 Germline	Right parietal, Right temporoocciptal	N	WBRT	Y	233	GemOX	24
5	No testing	Left frontal	Y	N	N	975	GTX	31
6	No testing	Multiple cerebral hemisphere, cerebellum	N	N	N	28	Supportive care	<1
7	No testing	Multiple cerebral	N	N	N	12	Supportive care	<1
8	No testing	Right frontal then parietal, cerebellum	N	SRS then WBRT (new lesions)	N	165	Gemcitabine	30
9	No testing	Right frontal, Left parietal, Left frontal	N	N	N	20	Gemcitabine plus irinotecan	7
10	KRAS G12D	Precentral gyrus, cerebellum	N	WBRT	N	50	Gemcitabine	9
11	No testing	Left frontal, right temporal, left occipital	N	N	N	11	GemOX	12
12	No testing	Multiple cerebral hemisphere	N	N	N	21	Gemcitabine plus erlotinib	22
13	No testing	Left occipital	N	SRS	N	56	GemOX	18
14	No testing	Left frontal, Left temporal	N	WBRT	N	27	Supportive care	<1
15	No testing	Left frontal, left parietal, cerebellum	N	WBRT	N	193	Unknown	6
16	No testing	Left frontal, Right occipital	Y	WBRT	N	656	Cisplatin plus gemcitabine	39
17	No testing	Left frontal	N	SRS	N	184	GemOX	16
18	No testing	Left parietal	N	N	N	41	FOLFIRINOX	43
19	No testing	Multiple cerebral hemisphere	N	WBRT	Y	23	GemOX	18
20	No testing	Right frontal, superior vermis	Y	WBRT	N	26	GTX	29
21	No testing	Left hemisphere, cerebellum	N	N	N	7	FOLFIRINOX	10
22	BRCA1 Germline	Left frontal, right occipital	N	N	N	23	Cisplatin plus gemcitabine +/−PARP inhibitor	22
23	KRAS G12V, TP53 1251F	Left Frontal, left precentral gyrus	N	WBRT	N	76	FOLFIRINOX	57
24	BRCA1 Germline	Right Temporal lobe, Cerebellum	N	WBRT	Y	118	Cisplatin plus gemcitabine +/−PARP inhibitor	14