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. 2019 Sep 18;10:1047. doi: 10.3389/fphar.2019.01047

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Copyright © 2019 Webster, Darling, Uversky and Blair

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intrinsic disorder profiles generated for human HspB1 (UniProt ID: P04792), HspB2 (UniProt ID: Q16082), HspB3 (UniProt ID: Q12988), HspB4 (UniProt ID: P02489), HspB5 (UniProt ID: P02511), HspB6 (UniProt ID: O14558), HspB7 (UniProt ID: Q9UBY9), HspB8 (UniProt ID: Q9UJY1), HspB9 (UniProt ID: Q9BQS6), and HspB10 (UniProt ID: Q14990), visualized as the mean of 6 commonly used disorder predictors from the PONDR family, PONDR^® VLXT, PONDR^® VSL2, PONDR^® VL3, PONDR^® FIT, IUpred_short and IUpred_long. In these plots, disorder score exceeding the 0.5 threshold correspond to intrinsically disordered regions, whereas disorder score ranging from 0.2 to 0.5 show flexible regions. The light cyan shade around disorder predisposition curves represents error (SD) distribution. The grey shaded background corresponds to the ACD of each sHsp sequence to facilitate discrimination from the terminal domains.