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. 2019 Sep 18;10:1047. doi: 10.3389/fphar.2019.01047

Table 1.

sHsp expression and relevance for neurodegenerative diseases.

HspB (alias) Normal brain expression Stress inducible neuronal expression Interactions with amyloidogenic proteins Effect on aggregation Association with neurodegenerative disease
HspB1 (Hsp27) Protein (Quraishe et al., 2008)
mRNA (Kirbach and Golenhofen, 2011)
Heat (Kirbach and Golenhofen, 2011)
Oxidative (Bartelt-Kirbach and Golenhofen, 2014; Bartelt-Kirbach et al., 2017)
Aβ (Ojha et al., 2011b)
tau (Shimura et al., 2004; Freilich et al., 2018)
α-Syn (Bruinsma et al., 2011; Cox et al., 2018)
SOD-1 (Yerbury et al., 2013)
TDP-43 (Wan et al., 2015)
↑Aβ (Ojha et al., 2011b)
↓Aβ (Wilhelmus et al., 2006a; Yoshiike et al., 2008)
↓Tau (Abisambra et al., 2010; Baughman et al., 2018; Freilich et al., 2018; Mok et al., 2018)
↓α-Syn (Bruinsma et al., 2011; Cox et al., 2018)
↓ polyQ (Vos et al., 2010)
AD (Wilhelmus et al., 2006c; Björkdahl et al., 2008; Yu et al., 2018)
HD (Brehme et al., 2014)
PD ( Zhang et al., 2005; Brehme et al., 2014)
HspB2 (MKBP) mRNA (Kirbach and Golenhofen, 2011) α-Syn (Bruinsma et al., 2011) ↓α-Syn (Bruinsma et al., 2011) AD (Wilhelmus et al., 2006c; Yu et al., 2018)
HD (Brehme et al., 2014)
PD (Brehme et al., 2014)
HspB3 (Hsp17) mRNA (Kirbach and Golenhofen, 2011) AD (Brehme et al., 2014)
HspB4 (αA-crystallin) ↓ polyQ (Vos et al., 2010)
HspB5 (αB-crystallin) Protein (Quraishe et al., 2008)
mRNA (Kirbach and Golenhofen, 2011)
Heat (Kirbach and Golenhofen, 2011)
Oxidative (Bartelt-Kirbach and Golenhofen, 2014; Bartelt-Kirbach et al., 2017 )
Aβ (Shammas et al., 2011)
α-Syn (Rekas et al., 2004; Waudby et al., 2010; Bruinsma et al., 2011; Cox et al., 2018)
polyQ (Robertson et al., 2010)
SOD-1 (Yerbury et al., 2013)
↓Aβ (Wilhelmus et al., 2006a; Shammas et al., 2011)
↓α-Syn (Rekas et al., 2004; Waudby et al., 2010; Bruinsma et al., 2011)
AD (Wilhelmus et al., 2006c; Björkdahl et al., 2008)
HD (Brehme et al., 2014)
PD (Brehme et al., 2014)
ALS (Gorter et al., 2018)
HspB6 (Hsp20) Protein (Quraishe et al., 2008)
mRNA (Kirbach and Golenhofen, 2011)
Oxidative (Bartelt-Kirbach and Golenhofen, 2014) Aβ (Cameron et al., 2014)
α-Syn (Bruinsma et al., 2011)
↓Aβ (Wilhelmus et al., 2006a)
↓α-Syn (Bruinsma et al., 2011)
↓ polyQ (Vos et al., 2010)
AD (Wilhelmus et al., 2006c)
HspB7 (cvHsp) Protein (Uhlén et al., 2015)
mRNA (Quraishe et al., 2008)
↓↓ polyQ (Vos et al., 2010)
HspB8 (Hsp22) Protein (Quraishe et al., 2008)
mRNA (Kirbach and Golenhofen, 2011)
Heat (Kirbach and Golenhofen, 2011)
Oxidative (Bartelt-Kirbach and Golenhofen, 2014)
Aβ (Wilhelmus et al., 2006b)
α-Syn (Bruinsma et al., 2011)
↓Aβ (Wilhelmus et al., 2006b)
↓ α-Syn (Bruinsma et al., 2011)
↓ polyQ (Vos et al., 2010)
AD (Brehme et al., 2014; Wilhelmus et al., 2006b)
HD (Brehme et al., 2014)
ALS (Gorter et al., 2018)
HspB9 (CT51) ↓ polyQ (Vos et al., 2010)
HspB10 (ODFP1)

, increased; , reduced