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DNA damage response inhibitors in clinical development.
| Target | Compound |
|---|---|
| BER | |
| PARP | Olaparib |
| Rucaparib | |
| Niraparib | |
| Talazoparib | |
| Veliparib | |
| APE1 | Methoxyamine |
| HRR | |
| ATR | VX-970 |
| AZD6738 | |
| NHEJ | |
| DNA-PKcs | MSC2490484A |
| CC-115 | |
| Checkpoint inhibitors | |
| CHK1 | GDC-0575 |
| MK-8776 | |
| CHK1 and CHK2 | LY2606368 |
| PF-00477736 | |
| ATM | AZD0156 |
| WEE1 | AZD11775 |
