Figure 6.

Circos-style plot of genome-wide association study data integrating gene-based and ROH-based findings. Starting from the outside, tracks denote: frequency of sROH segments prior to CNV filtering, frequency of sROHs outside CNV regions, frequency of CNV loss events, frequency of CNV gain events, joint distribution of CNV segments (regions excluded from ROH analyses), association results. The last track highlights genomic locations with findings that survived multiple corrections for gene-based association tests (in black) and findings at p < 0.0001 for sROH association analyses (blue) as well as the finding from the GRIA4 (purple) region that survived corrections for multiple testing.