Table 3.
Nominally significant (at P < .0001) associations between sROHs and Aurora.
| sROH | B | SE | T | P | Adjusted P | Chr | Start | End | Length | Carriers | Gene | Phen |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| sROH_17583 | 22.20 | 4.93 | 4.50 | 9.19 × 10-6 | 0.073441885 | 11 | 105,405,895 | 105,482,024 | 76,130 | 9/354 | GRIA4 | Aurora-F |
| sROH_17584 | -20.89 | 5.26 | -3.98 | 8.53 × 10-5 | 0.292376267 | 11 | 105,482,025 | 105,541,743 | 59,719 | 8/354 | GRIA4 | Aurora-G |
| sROH_17584 | 23.64 | 5.22 | 4.53 | 8.20 × 10-6 | 0.073441885 | 11 | 105,482,025 | 105,541,743 | 59,719 | 8/354 | GRIA4 | Aurora-F |
| sROH_17585 | 22.10 | 5.61 | 3.94 | 9.89 × 10-5 | 0.316240857 | 11 | 105,541,744 | 105,614,894 | 73,151 | 7/354 | GRIA4 | Aurora-F |
| sROH_17586 | 27.68 | 6.01 | 4.61 | 5.69 × 10-6 | 0.073441885 | 11 | 105,614,895 | 105,645,648 | 30,754 | 6/354 | GRIA4 | Aurora-F |
| sROH_17587 | -28.75 | 6.59 | -4.36 | 1.69 × 10-5 | 0.115640555 | 11 | 105,645,649 | 105,844,065 | 198,417 | 5/354 | GRIA4 | Aurora-G |
| sROH_17587 | 26.82 | 6.61 | 4.05 | 6.18 × 10-5 | 0.269457038 | 11 | 105,645,649 | 105,844,065 | 198,417 | 5/354 | GRIA4 | Aurora-N |
| sROH_17587 | 33.59 | 6.52 | 5.15 | 4.36 × 10-7 | 0.020933945 | 11 | 105,645,649 | 105,844,065 | 198,417 | 5/354 | GRIA4 | Aurora-F |
| sROH_17588 | 33.18 | 7.34 | 4.52 | 8.52 × 10-6 | 0.073441885 | 11 | 105,844,066 | 105,923,564 | 79,499 | 4/354 | KBTBD3, GRIA4, MSANTD4 | Aurora-N |
| sROH_17588 | -31.42 | 7.37 | -4.27 | 2.57 × 10-5 | 0.153851824 | 11 | 105,844,066 | 105,923,564 | 79,499 | 4/354 | KBTBD3, GRIA4, MSANTD4 | Aurora-G |
| sROH_17588 | 35.79 | 7.31 | 4.90 | 1.49 × 10-6 | 0.035692842 | 11 | 105,844,066 | 105,923,564 | 79,499 | 4/354 | KBTBD3, GRIA4, MSANTD4 | Aurora-F |
| sROH_20937 | 29.54 | 7.39 | 4.00 | 7.77 × 10-5 | 0.286862153 | 15 | 41,063,245 | 41,105,658 | 42,414 | 4/354 | DNAJC17, C15orf62, ZFYVE19 | Aurora-V |
| sROH_23251 | -18.06 | 4.50 | -4.01 | 7.30 × 10-5 | 0.286862153 | 19 | 8,999,675 | 9,001,832 | 2,158 | 11/354 | MUC16 | Aurora-V |
| sROH_23252 | -16.82 | 4.15 | -4.05 | 6.18 × 10-5 | 0.269457038 | 19 | 9,001,833 | 9,024,870 | 23,038 | 13/354 | MUC16 | Aurora-V |
| sROH_23253 | -16.46 | 4.00 | -4.11 | 4.85 × 10-5 | 0.258308827 | 19 | 9,024,871 | 9,043,020 | 18,150 | 14/354 | MUC16 | Aurora-V |
sROH, unique surrogate ROH identifier; B, effect size (in standardized scores units); SE, standard error; t, t-value for regression coefficient. Adjusted P—p-value adjusted using the Benjamini–Hochberg correction. Adjusted P-values < 0.05 are shown in bold. Phen, phenotype.