Table 4.
Risk factors associated with annual exacerbator
| Parameter (n=390) | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | |
| Age, years | 1.032 | 1.003–1.062 | 0.031 | 1.025 | 0.993–1.058 | 0.130 |
| Male | 0.833 | 0.205–3.386 | 0.798 | |||
| Smoking amount, pack-year | 1.008 | 1.000–1.016 | 0.057 | 1.007 | 0.999–1.016 | 0.103 |
| Current smoker | 0.851 | 0.526–1.375 | 0.510 | |||
| BMI, kg/m2 | 0.941 | 0.880–1.007 | 0.078 | 0.980 | 0.909–1.057 | 0.601 |
| Family history of BA | 1.033 | 0.571–1.868 | 0.915 | |||
| FEV1 (% predicted)* | 0.978 | 0.965–0.990 | 0.001 | 0.982 | 0.968–0.996 | 0.012 |
| 6MWD, m | 0.999 | 0.997–1.002 | 0.534 | |||
| Charlson’s comorbidity score | 0.917 | 0.650–1.295 | 0.624 | |||
| Blood eosinophil count (/mm3) | 1.000 | 0.999–1.000 | 0.423 | |||
| mMRC, initial | 1.333 | 1.070–1.660 | 0.010 | 1.058 | 0.831–1.347 | 0.645 |
| SD of mMRC during 1 year | 2.015 | 1.198–3.392 | 0.008 | |||
| Variable group (vs Consistent group)* | 2.280 | 1.390–3.741 | 0.001 | 1.963 | 1.165–3.305 | 0.011 |
| History of AE-COPD in previous 1 year* | 2.282 | 1.365–3.813 | 0.002 | 2.036 | 1.185–3.499 | 0.010 |
Note: *Indicated P-value <0.05.
Abbreviations: Annual exacerbator, AE-COPD/year ≥1; BMI, body mass index; FEV1, forced expiratory volume in 1 second; 6MWD, 6 min walk distance; mMRC, modified Medical Research Council; SD, standard deviation; AE-COPD, acute exacerbation of chronic obstructive pulmonary disease; OR, odds ratio; CI, confidential interval.