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. 2019 Sep 18;6:314. doi: 10.3389/fvets.2019.00314

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Copyright © 2019 Sandercock, Barnett, Coe, Downing, Nirmal, Di Giminiani, Edwards and Freeman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Probe-set signal intensities of selected significantly down-regulated DRG genes expressing G-protein-coupled neurotransmitter receptors after tail amputation in network cluster A associated with inflammatory and neuropathic pain signaling (A) GRM4, Glutamate metabotropic receptor 4; (B) GRM8, Glutamate metabotropic receptor 8; (C) CHRNA3, Cholinergic receptor nicotinic alpha 3 subunit; (D) CHRNB4, Cholinergic receptor nicotinic beta 4 subunit; (E) CHRM4, Cholinergic receptor muscarinic 4; (F) OPRM1, Glutamate metabotropic receptor 8; (G) ADORA1, Adenosine A₁ receptor; (H) P2RY14, Purinergic receptor P2Y14. All signal intensity data values are shown by treatment group (open circles, n = 95) along with group means ± SEM.