Table 3.
Functional groups, family member/subunit, and their associated significantly (3-way ANOVA; p < 0.05) down-regulated DRG pain genes* after tail amputation in network Cluster A common to GeneCard inflammatory and neuropathic pain gene lists.
| Functional group | Member/subunit | Gene symbol |
|---|---|---|
| Ion channel | Potassium (K+) channel subunit | KCNA4, KCNG4, KCNQ3, KCNH6, KCNV1, KCNT2, KCNK1, KCNK10 |
| Sodium (Na+) channel subunit | SCN1A, SCN4B | |
| Calcium (Ca2+) channel subunit | CACNA1A, CACNA2D | |
| Acid sensing proton (H+) channel | ASIC | |
| ATPase Na+/K+ subunit | ATP1A1 | |
| Solute transporter | Organic anion transporter family member | SLCO5A1 |
| Na+/Ca2+ exchanger family member | SLC8A2 | |
| Na+/H+ exchanger family member | SLC9A9 | |
| Receptor | Gamma-aminobutyric acid (GABA) receptor subunit | GABRB2, GABRB3, GABBR1, GABBR2 |
| Metabotropic glutamate receptor | GRM4, GRM8 | |
| Cholinergic receptor subunit | CHRNA3, CHRNB4, CHRM4 | |
| Purinergic receptor | P2RY14 | |
| Adenosine receptor | ADORA1 | |
| Opioid receptor | OPRM1 |
*
Consistently down-regulated across all time points after tail amputation (T+1, T+8, and T+16 weeks) and common to both tail treatment age groups (3- and 63-days).