Table 4.
Functional groups, subgroups, and their associated significantly (3-way ANOVA; p < 0.05) up-regulated DRG pain genes* after tail amputation in network Cluster B common to GeneCard inflammatory and neuropathic pain gene lists.
| Functional group | Member | Gene symbol |
|---|---|---|
| Transcription factor | Activating transcription factor 3 | ATF3 |
| Jun proto oncogene | JUN | |
| Neuropeptide | Proenkephalin | PENK |
| Somatostatin | SST | |
| Galanin/GMAP propeptide | GAL | |
| Neuropeptide Y | NPY | |
| Adenylate cyclase activating polypeptide | ADCYAP1 | |
| Inflammatory intermediate | Phospholipase A2 group III | PLA2G3 |
| Prostaglandin-endoperoxide synthase 2 | PTGS2 | |
| Interleukin 24 | IL24 | |
| Receptor | 5-Hydroxytryptamine (serotonin) receptor | HTR2A |
| Angiotensin II receptor | AGTR2 | |
| Neuromedin U receptor | NMUR2 | |
| Neuropeptide S receptor | NPSR | |
| Neurotrophin receptor tyrosine kinase | NTRK3 | |
| Interleukin 4 receptor | IL4R |
*
Consistently up-regulated across all time points after tail amputation (T+1, T+8, and T+16 weeks) and common to both tail treatment age groups (3- and 63-days).