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. 2019 Sep 20;12:7773–7784. doi: 10.2147/OTT.S222097

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© 2019 Zhou et al.

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Intratumoral 9597/IL-12 cell injection inhibits HCC growth. (A) The tumor volume is smaller in the 9597/IL-12 group than in the 9597/plasmid and PBS groups on days 7, 14, 21, and 28 post-treatment; (B) HE staining shows infiltration of plenty of inflammatory cells in the grafted tumor interstitium with tissue necrosis in the 9597/IL-12 group, and the arrows indicate the necrotic tissues (scale bar = 200 μm); (C) HE staining shows lower degree of inflammatory cells infiltration and tissue necrosis in the 9597/plasmid than in the 9597/IL-12 group (scale bar = 200 μm); (D) HE staining shows lower degree of inflammatory cells infiltration and tissue necrosis in the PBS group than in the 9597/IL-12 group (scale bar = 200 μm). *P < 0.05; **P < 0.01.