Table 2.

List of PPARα target genes that are less expressed in Epac1/2^−/− mice.

ID	Gene symbol	Protein name	prePH FC	postPH FC
P55096	Abcd3	ATP-binding cassette sub-family D member 3	−1.23	−1.19, ns
Q921H8	Acaa1a	3-ketoacyl-CoA thiolase A, peroxisomal	−1.51	−1.58
Q8VCH0	Acaa1b	3-ketoacyl-CoA thiolase B, peroxisomal	−1.64, ns	−2.25
P51174	Acadl	Long-chain specific acyl-CoA dehydrogenase, mitochondrial	−1.11, ns	−1.24
P45952	Acadm	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	−1.08, ns	−1.25
Q9QYR9	Acot2	Acyl-coenzyme A thioesterase 2, mitochondrial	−1.61	−4.18
Q8BWN8	Acot4	Acyl-coenzyme A thioesterase 4	−1.78, ns	−1.95
Q9R0H0	Acox1	Peroxisomal acyl-coenzyme A oxidase 1	−1.25	−1.46
P47740	Aldh3a2	Fatty aldehyde dehydrogenase	−1.48, ns	−2.75
P52825	Cpt2	Carnitine O-palmitoyltransferase 2, mitochondrial	−1.02, ns	−1.24
P47934	Crat	Carnitine O-acetyltransferase	−1.59, ns	−1.92
O88833	Cyp4a10	Cytochrome P450 4A10	−2.01, ns	−3.93
Q91WL5	Cyp4a12a	Cytochrome P450 4A12A	−1.73	−1.73
O35728	Cyp4a14	Cytochrome P450 4A14	−9.89	−13.73
Q9CQ62	Decr1	2,4-dienoyl-CoA reductase, mitochondrial	−1.19, ns	−1.31
O35459	Ech1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial	−1.31	−1.35
Q9DBM2	Ehhadh	Peroxisomal bifunctional enzyme; Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase	−1.18, ns	−1.59
P51660	Hsd17b4	Peroxisomal multifunctional enzyme type 2;(3 R)-hydroxyacyl-CoA dehydrogenase; Enoyl-CoA hydratase 2	−1.20	−1.28
Q9Z211	Pex11a	Peroxisomal membrane protein 11A	−1.99	−2.36
Q9Z2Z6	Slc25a20	Mitochondrial carnitine/acylcarnitine carrier protein	−1.01, ns	−1.33

PrePH (WTprePH vs. Epac1/2^−/−prePH), postPH (WTpostPH vs. Epac1/2^−/−postPH), negative value: decreased protein expression in Epac1/2^−/− mice relative to wt mice. ns: not significant. FC: fold change. Please see the Supplementary M&M section for details regarding statistical analysis.