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. 2019 Sep 24;9:13797. doi: 10.1038/s41598-019-50310-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Top 30 most variable genes across all samples. Pairwise Euclidian distances between all samples were calculated from the normalised counts of genes with the maximum dispersion from the population mean and are represented by the column and row dendrograms. Heatmap tiles correspond to row z scores, centred and scaled upon the mean expression value for that gene across the dataset, with orange and blue tiles indicating increased or decreased expression relative to the population mean, respectively.