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. 2019 Sep 24;9:13753. doi: 10.1038/s41598-019-50276-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of chrysin-induced elevation of toxicity by CLDN1 overexpression in a spheroid model. RERF-LC-AI cells were plated on PrimeSurface96V multi-well plates, and then transfected with mock or CLDN1 expression vector. (A) The cells were incubated with DXR for 60 min at the concentrations indicated in the presence or absence of 10 μM chrysin. The fluorescence intensities of DXR in spheroids are shown as a percentage of the values in 0 μM. (B) After treating the cells with DXR for 24 h at the concentrations indicated in the presence or absence of chrysin, the viability of spheroid cells was measured. These values are represented as a percentage of mock. n = 3–4. **P < 0.01 and *P < 0.05 compared with mock. ^##P < 0.01, ^#P < 0.05 and NS, P > 0.05 compared with mock (Chr).