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. 2019 Sep 24;9:13753. doi: 10.1038/s41598-019-50276-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of luteolin and chrysin on the expression levels of CLDN1 and CLDN11. (A) RERF-LC-AI cells were treated with luteolin or chrysin at the indicated concentrations for 24 h. Cytotoxicity was measured using WST-1 assays. (B) The cells were treated with 10 μM luteolin (Lut) or 10 μM chrysin (Chr) for 24 h. The expression levels of CLDN1, CLDN11, and β-actin in cell lysates were examined by western blotting. The protein levels of CLDN1 and CLDN11 are shown as a percentage of values in the control cells (Cont). The full-length blot images are shown in Supplementary Fig. S2. (C) The cells were treated with 10 μM luteolin or 10 μM chrysin for 6 h. The mRNA levels of CLDN1 and CLDN11 are shown as a percentage of the values in control cells. n = 3–4. **P < 0.01, *P < 0.05, and NS, P > 0.05 compared with 0 μM or the control.