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. 2019 Sep 24;9:13753. doi: 10.1038/s41598-019-50276-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of chrysin and CA-Akt on anticancer drug-induced cytotoxicity and tight junction permeability. (A) RERF-LC-AI cells were treated with DXR or CDDP in the presence or absence of 10 μM chrysin (Chr) for 24 h. Cytotoxicity was measured using WST-1 assays. (B) The cells were plated on transwell inserts and treated with 10 μM chrysin or 20 μM LY-294002. TER and transepithelial DXR flux were analyzed using a volt ohmmeter and fluorescence spectrometry, respectively. (C) The cells were transfected with mock or CA-Akt vector, and then treated with 10 μM chrysin. TER and transepithelial DXR flux were analyzed. n = 3–4. **P < 0.01, *P < 0.05, and NS, P > 0.05 compared with the control.