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. 2019 Sep 24;9:13775. doi: 10.1038/s41598-019-50302-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circos plot⁵⁴ showing genetic variation between five individual MutaMouse animals from a colony maintained at Health Canada. Links represent structural translocations identified in all mice sequenced. Each outside track has 5 individual components, one for each mouse sequenced (MutaMouse HC 1, 2, 3, 4, 5, from inside to out). The tracks from inside to outside represent (1) runs of homozygosity (where blue is homozygous and red is heterozygous – immediately adjacent to chromosome numbering), (2) Red track: SNV density per megabase of DNA sequence for all SNVs, (3) Blue track: SNV density for novel SNVs, (4) Orange track: SNV density for variants inherited from DBA/2J exclusively, (5) Green track: SNV density for variants inherited from BALB/cJ exclusively, and (6) Grey track: SNV density for variants inherited from both parents. The next tracks show copy number variants for the parental strains DBA/2J and BALB/cJ (orange and green, respectively), followed by copy number variants in MutaMouse predicted by CNVnator (blue). Finally, the line plots show the log2 values for aCGH probes averaged over 1 megabase intervals, with red highlights showing deleted segments and green highlights showing duplicated segments for each mouse.