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. 2019 Sep 24;9:13775. doi: 10.1038/s41598-019-50302-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of variants discovered in MutaMouse colonies that were geographically isolated for 23 years of breeding (78 generations). (A) More SNVs of parental origin were retained in the Health Canada colony than the Covance colony, which experienced a population bottleneck circa 2006. The number of putative de novo SNVs is comparable, suggesting that the germline mutation rates do not differ between the populations. (B) On a phylogenetic tree, the MutaMouse colony from Covance forms a distinct branch, which is consistent with our finding that (C) Animals from the Covance MutaMouse colony have higher genotype discordance with animals from Health Canada than with each other.