Table 2.
Variants (SNVs and short indels) identified in MutaMouse in the genes from pathways that are important for genetic toxicology studies.
| Animals | Cancer Progressiona (642 genes) | Cell Cycleb (1,434 genes) | DNA repairb (408 genes) | Xenobiotic Metabolismb (45 genes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variants within genes | Non synonymous | SIFT score deleteriousc | Variants within genes | Non synonymous | SIFT score deleteriousd | Variants within genes | Non synonymous | SIFT score deleteriousc | Variants within genes | Non synonymous | SIFT score deleteriousc | |
| MutaMouse 1 |
93,708 (15,099)c |
301 (34) |
52 (8) |
133,383 (21,452) |
659 (47) |
98 (23) |
35,592 (5,567) |
244 (3) |
27 (0) |
3,483 (630) |
13 (1) |
2 (1) |
| MutaMouse 2 | 80,922 (14,455) |
313 (38) |
54 (10) |
135,318 (21,943) |
598 (47) |
96 (24) |
34,416 (5,475) |
222 (9) |
27 (4) |
3,295 (586) |
11 (1) |
2 (1) |
| MutaMouse 3 | 98,330 (15,681) |
354 (45) |
67 (20) |
147,108 (23,716) |
745 (58) |
117 (29) |
39,493 (6,055) |
246 (3) |
27 (1) |
3,469 (643) |
11 (1) |
2 (1) |
| MutaMouse 4 | 89,172 (14,906) |
324 (44) |
65 (20) |
136,668 (21,821) |
621 (51) |
102 (26) |
37,618 (5,802) |
238 (7) |
30 (3) |
3,326 (583) |
11 (1) |
2 (1) |
| MutaMouse 5 | 110,565 (16,748) |
327 (39) |
56 (11) |
138, 297 (22,785) |
645 (49) |
98 (23) |
39,869 (6,156) |
258 (5) |
28 (1) |
3,278 (592) |
11 (1) |
2 (1) |
| MutaMouse Covance Female |
71,057 (9,512) |
2,379 (37) |
42 (20) |
111,611 (14,304) |
541 (31) |
91 (17) |
28,344 (3,663) |
198 (6) |
29 (3) |
2,932 (362) |
10 (1) |
2 (1) |
| MutaMouse Covance Male |
71,513 (9,820) |
242 (44) |
43 (22) |
112,389 (14,734) |
545 (36) |
90 (17) |
28,474 (3,478) |
199 (7) |
29 (3) |
2,934 (354) |
10 (1) |
2 (1) |
| Common |
55,389 (7,682) |
219 (22) |
36 (5) |
95,155 (12,129) |
479 (35) |
68 (18) |
27,121 (3,309) |
184 (2) |
19 (0) |
2,979 (358) |
11 (1) |
2 (1) |
| Total | 132,221 (24,470) |
407 (66) |
71 (26) |
180,472 (34,966) |
870 (74) |
129 (32) |
46,554 (8,808) |
280 (11) |
34 (5) |
3,938 (904) |
13 (1) |
2 (1) |
aCOSMIC cancer genes (Mouse homologs).
bRetrieved using BioMart.
cSIFT scores calculated using Ensembl Variant Effect Predictor; only canonical transcripts reported (i.e., only one consequence is reported per variant).
dNot reported in dbSNP 142.
eSubset of variants that are present in all mice.
fTotal count of variants (i.e., present in 1 or more mouse).